Assignment Example | Topics and Well Written Essays - 2250 words

Assignment Example The santa factor may bind to its specific receptor in the cytosol or on the nuclear membrane. This causes the formation of a receptor-ligand complex that then acts as an effector molecule on the DNA (transcription factor or co-factor). This is basically transcription regulation. Several pathways can be implicated. They include; acting as specificity factors, repressors, activators or enhancers. Taking that the santa-receptor complex acts as a repressor for gene transcription; this complex may bind to the operator portion of the DNA and prevent the DNA polymerase from transcribing a specific gene, or genes. In the given case, the gene coding for FuIL protein will not be transcribed. The result is that no mRNA is formed, and subsequently no synthesis of the protein. Alternatively, it may act as a post translational modifier. Here, it will modify the folding structure of the FuIL protein, and subsequently lead to the ‘exposure’ of the degron on the protein for action by ubi quitin conjugating enzymes E1, E2 and E3. Combinations of different ubiquitin-conjugating enzymes and other factors constitute other pathways of the ubiquitin system, each of which conjugates a specific subset of proteins. There is some evidence that certain sequence elements and structural motifs of target proteins are degradation signals which mark them for ubiquitination by a particular model of the ubiquitin system and for eventual degradation. When looking at the santa factor as a direct promoter of protein degradation, it may diffuse into the cell and bind to the FuIL protein (like an enzyme-substrate complex) causing a conformational change in its structure that exposes the normally hidden degron. As a ligand, it may also bind to a receptor that catalyzes the phosphorylation forming a phosphodegron which is specific to certain multiunit ubiquitin ligases. An example would be a serpentine receptor. The serpentine receptors are coupled to a plasma membrane phospholipase C that cleaves PIP2 to diacylglycerol and IP3. By opening calcium channels in the endoplasmic reticulum, IP3 raises cytosolic calcium. Diacylglycerol and calcium act to activate protein kinase C, which phosphorylates and changes the conformation of the protein. This may be exposure of the degron. This then leads to facilitated function of ubiquitin and proteasome complexes that target and destroy specific proteins. Polyubiquitin tagging of proteins (ubiquitin attachment site in proteins is commonly a lysine side chain) by specific enzymes (E1,2 and 3) provides the major source of selectivity in the process of degradation, whereas the 26S proteasome complex performs the protein unfolding necessary for cleavage of the ubiquitin tagged proteins. This also provides an avenue for selectivity for the FuIL, as the E3 may bind to the santa, become allosterically modified and thus become specific to the FuIL. Such a mechanism is evident where the growth-regulating plant indole auxin binds to a spec ific E3 ligase, and forms part of a protein-binding interface that allows high-affinity interaction with specific protein substrates. (Sharon M) ii) Santa Response Element. The santa response element acts as a secure site for binding of RNA polymerase and the required transcription factors such as the SREB. It thus acts as an operator for the operon in question. The SREB molecule requires transport into the nucleus so as to exert

Critical Assessment Of The Future Of Coffee As A Commodity Trade Essay

Critical Assessment Of The Future Of Coffee As A Commodity Trade - Essay Example This issue has been addressed by a diverse array of institutions with different approaches in order to find adequate solutions to short-term and long-term conditions of the coffee market as a commodity that is mainly produced in LCDs and developing countries where the levels of poverty are pretty high. The Food and Agriculture Organization (FAO). (2004) published a report entitled "The state of agricultural commodity markets 2004" with the main concern of addressing the issue of agricultural commodity economies with the intention of finding workable solutions to the challenges ahead. Jacques Diouf, FAO Director-General, stated the following in the Foreword: "The price of coffee plummeted 70 percent between 1997 and 2001, threatening the livelihoods of an estimated 25 million people who depend on coffee and triggering food emergencies in several countries in Africa and Central America." (Food and Agriculture Organization, 2004). This is really a very critical situation. There are several reasons behind it. It is a complex problem that has to be assessed from a multi-lateral perspective taking into account all the stakeholders, especially the small farmers in LDCs and developing countries. In its report, FAO acknowledges the greater productivity of the coffee sector. At the same time it points out that the main beneficiaries are the developed countries producers and consumers: "Advances in agricultural productivity th... ers in better-endowed and more-developed regions that have been able to take advantage of productivity gains to strengthen their position on world markets." (Food and Agriculture Organization, 2004). The FAO report also addresses the issue of concentration of a few big companies in the global market. This troublesome factor in the overall scenario of commodity trading is stated as follows: "Another development in agricultural commodity markets has been the increasing concentration of market power in the hands of a few transnational corporations. Just three companies now control almost half the coffee roasting in the world, for example, and the 30 largest supermarket chains control almost one-third of grocery sales worldwide." (Food and Agriculture Organization, 2004). Daniele Giovannucci, Bryan Lewin and Panayotis Varangis published a report for the World Bank entitled "Coffee markets: New paradigms in global supply and demand". Among their findings, the following statements picture a negative situation for producers in LCDs and developing countries regarding coffee economic viability: "Most of the world's coffee is produced by smallholders utilizing just a few hectares of land. In the past year, many reports have confirmed the heavy toll on farmers that have had to sell below cost or even give up their coffee farms because current prices do not even cover the most basic costs of harvesting and transport to market, and estimate economic losses for small coffee farmers at US$4.5 billion per year." (Giovannucci, Lewin, & Varangis, 2004). These losses are extremely burdensome for small farmers who mostly live in LDCs and developing countries. Finding a solution by raising prices has its ups and downs as can be seen in an article about commodity trade published

Pilgrim Tourism To Holy Places

Pilgrim Tourism To Holy Places Tourism is the temporary, short-term movement of people to destination outside the places where they normally live and work and their activities during the stay at each destination. It includes movements for all purposes (1976, Tourism Society of England,1976) . Tourism has been described in various ways but may be thought of as the connection and experience arising out of the journeys and temporary stay of people travelling primarily for leisure and recreational purpose. Tourism is thus a multifaceted activity and geographically complex one as different services are sought and supplied at different stages from the origin to the destination. Tourism has emerged as one of the most important instruments to boost economic development in many of the countries across the globe as an engine for economic development, the earnings of foreign exchange, its contribution creation of employment. India has diverse culture and heritage in the North, it has the great Himalayas which gives tremendous opportunities for mountain tourism or adventure tourism. It provides great challenges and difficulties to mountaineers. In the Southern part of the country there is Indian Ocean which gives opportunities to beach tourism and attract large number of foreign and domestic tourists. In the North West there is Thar Desert with Aravalis mountains range. It is highly suitable for desert tourism and heritage tourism. In this way India have very rich natural resources like geographical and cultural diversity, forests, lakes, mountains, rivers and rivulets, sacred shrines, historic monuments and hospitable people, which are necessary for thriving tourism activity (Singh, 2002). Pilgrims with pilgrimage tourism is one of the fastest growing tourism in the world. Not only has it become an important component of the Indian life style (Adrian Ivakhiv, 2003 ) but it has had a profound impact on other peoples of the world and the environments in which they live. Pilgrim tourism to holy places (tirtha-yatra) is an ancient and continuing religious tradition of the Culture of Hindus. Here religion, as a cultural dimension, assumes the vital role and central focus of tourism in which the tourists (pilgrims) from all strata of the Hindus participate. In pilgrim tourism, the dimension of religion forms the basis of tourism of pilgrimage by offering the reward of purification of the soul and attainment of objectives related to the problems of routine life. Hindus from time immemorial were attracted to their numerous holy sites spread throughout India. Pilgrimage is thus a pan-human and pan Indian phenomenon, the meaning of which within the traditional structure of each religion, if not, within castes and communities. According to Skandapurana (a religious treatise), truth, forgiveness, control of senses, kindness to all living beings and simplicity is tirtha. Thus, tirtha yatra not only means physically visiting the holy places but implies mental a nd moral discipline as well. It has rightly said that following the Vedic period, the practice of religious tourism or pilgrimage seems to have gained increased popularity as evident from the great epic Mahabharata (Bhardwaj 1973: 5). The number of pilgrimage sites in India is extremely large but some primary pilgrimage sites include the four Dhams, the Seven Sacred cities and their primary temples, Ashtvinayakas, twelve Jyotirlings, Svaymbhu and Pancha Bhutta linga Temples, the Shakti Pithas, the Kumbha Mela sites, major Vaishnava sites, the Nava Graham Sthalas, the Seven Sacred Rivers, the four Muths of Sri Adi Sankaracharya, the Arupadaividu, Dargah of Hazrat Nizamuddin Auliva, Jama Masjid, Dargah of Muinuddin Chishti, Hazrathbal Mosque, Haji Ali Mausoleum, Church of St. Catejan, Church of the Sacred Heart, Patna Sahib, Sachkhand Sahib, Hemkund Sahib, Little Mount and certain other places that do not fit into any of the categories listed here. In India all temples, Gurudwaras, Mosques and Churches are considered sacred places. As is evident from the list these sites are not related with one religion only and therefore, they attract people of different religions for pilgrimage. Further, many of such places are visited by pilgrims of various religions. It is worth mentioning that Uttarakhand has many important religious places which are quite popular at national level. Some of these places are well known at the international level as well. A brief description of of such places has been given as Haridwar, Rishikesh and Neelkanth in Uttaranchal. Tourism in Uttarakhand Uttarakhand became the 27th state of the Republic of India on November 9, 2000, which was carved out of Uttar Pradesh. It occupies an area of 51,125 sq km and a population of about __________ (__________ per sq km).The entire region is geographically important and is comprised of the two distinct parts i.e. eastern part (known as Kumaon) and western part (known as Garhwal). Uttarakhand is surrounded by a number of states like Himachal Pradesh, and Uttar Pradesh and country like Nepal. Uttarakhand give a distinct sense of tourism practices such as, Adventure tourism activities, leisure activities, wild life national parks and eco tourism activities etc. It is also a home of several religious places belonging to the Hindus and the Sikhs like Kedarnath, Badrinath, Yamunotri, Gangotri, Lokpal and Hemkundsahib. To promote tourism Uttar Pradesh Parvatiya Vikas Nigam was established on 30th March 1971, with authorized capital of Rs. 2 crore, under Companies Act 1956. The main objective of this government body was the development of seven hilly districts i.e. Haridwar, Dehradun, Tihri, Pauri, Uttarkashi, Chamouli and Rudraprayag. After this on 31st March 1976, two more Government companies i.e. Garhwal Mandal Vikas Nigam and Kumaon Mandal Vikas Nigam were established for the development of these regions. The main objectives of these apex bodies in the context of tourism were to work in the area of tourism development and provide basic tourism infrastructure facilities, to promote tourism, a state tourism policy was formulated in 2002 in which emphasis was given on three things i.e. development of eco-friendly tourism with the help of both the public and private sectors and local communities, promote tourism as a source of economic growth by employment and revenue generation, develop Uttarakhand as a leading tourist destination and place Uttarakhand on the tourist map. To promote the pace of tourism a Board named Uttarakhand Tourism Development Board was also established in 2002. This board is the supreme institute which gives suggestions to the government related to all tourism matters. Along with tourism this board also works as a regulatory and licensing authority. It has a negative impact on environment too. Degradation of forestland in and around the tourist places and garbage problems due to booming up of tea stalls and shops and as well as mass tourism are the major environmental problems. All above facts relating to the Uttarakhand reveal that the state government view tourism as a source of economic development and employment generation. They have shown their interest in infrastructure development on public-private participation. Further, efforts have been made to keep environmental aspects into consideration while developing tourism. If these steps implemented properly can lead to tourism growth in the above states. The presentation is written for tourism industry analysts and public officials, who would like to better understand, evaluate, or possibly reduce the negative impact of tourism in Uttarakhand. Haridwar Haridwar is regarded as most sacred destination among Hindu pilgrimages. A staggering number of pilgrims visited Haridwar every year. Haridwar is also a historic and cultural destination, older than many other ancient towns in the world, and is deeply rooted in the history and development of Hinduism and Indian culture from its earliest days. Haridwar meaning à ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒâ€¦Ã¢â‚¬Å"Gateway to Godà ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ã‚  is one of the seven holiest places of the Hindus, located on the banks of River Ganges. With Ujjain, Nasik and Allahabad, Haridwar forms the four important pilgrimage centers of India where Kumbh Mela is celebrated after every 3 years rotated over these 4 destinations. Har-ki-Pauri is the most holy place where thousands of devotees take a dip. Haridwar is located around 200 km north east of Delhi and 54 km south of Dehradun and is probably the most important gateway to Uttarakhand by rail and road. It would also be justifiable to describe it as one of the most important à ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ãƒâ€¦Ã¢â‚¬Å"pilgrimage tourismà ¢Ãƒ ¢Ã¢â‚¬Å¡Ã‚ ¬Ã‚  destinations in India.

Digital Divide :: Essays Papers

Digital Divide The â€Å"Digital Define† is the distance between the people who have adequate access to technology and those who do not. As teachers, we have numerous avenues through which we can assist in narrowing the gap of the Digital Divide. Some suggestions are the following: 1. Gather teaching materials through sources such as: www.pbs.org/digitaldivide/about.html www.pbs.org/digitaldivide/learning.html www.siliconvallydigitaldivide.net www.ed.gov/free www.fcs.gov/resources.html 1-800-257-5126 2. Donate a computer, obtain a donated computer, or upgrade an obsolete one. Many organizations have been developed to assist in this task; a few are as follows: Share the Technology - www.sharetechnology.org Computers for Learning – www.computers.fed.gov NewDeal – www.newdealine.com Heaven – www.heavens.org 3. Keep informed about the most recent government initiatives, as well as what politicians and government officials have to say. A variety of Web sites can aid you in this undertaking; some are listed here: U.S. Department of Education, Office of Educational Technology – www.ed.gov/Technology Federal Communications Commission – www.fcc.gov.major.html Closing the Digital Divide – www.digitaldivide.gov The National Telecommunications and Information Administration – www.ntia.doc.gov/ntiahome/fttn99/contents.html The Digital Divide Network – www.digitaldividenetwork.org 4. Investigate the community access centers (CACs) in your area and spread the word about their availability. CACs include places such as libraries, community centers, schools, and other public-access locations. 5. Learn about model initiatives – successful models. A few projects include: The Digital Divide Project – www.washington.edu/wto/digital/resources/html NetDay – www.netday.org Alliance for Community Technology – www.communitytechnology.org The Foundry – www.thefoundry.org The Village Foundation – www.villagefoundation.org/PROGRAMS/pathways/technology/index.html PowerUP: Bridging the Digital Divide – www.powerup.org The Maine Laptop Program Lightspan, Inc. – www.lightspan.com Plugged In – www.pluggedin.org Neighborhood Network – www.hud.gov/nnwnnwindex.html 6. Explore opportunities for corporate support. A good place to start is www.wested.org/tie/grant.html#corporate. This site has a list of corporate and foundation funding sources and other grant related resources. The model initiative I chose to investigate is NetDay. NetDay is a project connecting students and their teachers in under-served communities with the necessary resources to facilitate learning through education technology. From this site, NetDay Compass is accessible. NetDay Compass is a teachers guide to educational technology resources. There are sections on developing technology plans, technology infrastructure, grant and funding, classroom support, and model high tech schools. Here teachers will find the information they need to include technology in education and narrow the gap of the digital divide. In the three years I have been teaching in Louisiana, I have seen numerous incidents of digital divide. However, one particular incident stands out in my mind the most. Last year, I had a Financial Math class made up of mostly juniors and seniors.

Employment Law Legal Process Paper Essay

To handle a complaint of discrimination effectively, an employer should have a basic understanding of the process and procedures used by the EEOC to enforce the federal laws that prohibit employment discrimination. By knowing in advance what to expect, an employer can best prepare its defense. EEOC ProcessAny individual who believes that his or her employment rights have been violated may file a charge of discrimination with EEOC. Charges may be filed by mail or in person at their nearest EEOC office. Once an employee or applicant files a charge, the EEOC then serves notice on the employer, usually by mail, that a charge has been filed against them. This notice normally includes a copy of the actual charge filed by the employee or applicant. All laws enforced by EEOC, except the Equal Pay Act, require filing a charge with EEOC before a private lawsuit may be filed in court. There are strict time limits within which charges must be filed. A charge must be filed with EEOC within 180 days from the date of the alleged violation, in order to protect the charging party’s rights. This 180-day filing deadline is extended to 300 days if the charge also is covered by a state or local anti-discrimination law (U.S. Equal Employment Opportunity Commission). Employers must understand that the persons who evaluate and decide the outcome of employment discrimination cases (the EEOC investigator, federal or state judge, and/or jury) have keen senses of fairness and expect that employees will be treated in a fair manner. As a result, employers are exposed to substantial liability for any acts, including perceived acts, of discrimination in the workplace. Employers should take any charge of discrimination seriously and the employer must keep in mind that, at a minimum, it needs to have a legitimate, non-discriminatory reason for taking the action in question. In addition, an employer’s response will be evaluated by persons who have a different perspective than the employer. What may appear to an employer, as a benign, routine employment action, can be perceived by a jury as the most pernicious, discriminatory deed. With this in mind, an employer should structure its response to show that its action was not only legal, but also fair (Bu reau of National Affairs, 2002). Resolving the Discrimination ChargeThe filing of the charge triggers an EEOC investigation into whether or not there is reasonable cause to believe that the employer did in fact illegally discriminate against an individual. An employer may be asked to submit a written statement of position to explain its version of events. At some point in the investigation, a fact-finding conference might be held (Bureau of National Affairs, 2002). Relatively informal, a fact-finding conference is attended by the charging party, respondent and necessary witnesses. No official record is made and witnesses are not placed under oath. Most employers bring counsel to the conference. After concluding its investigation, the EEOC makes a determination as to whether there is reasonable cause to believe that the alleged discrimination occurred. The investigation starts with a review of all documents in the employee’s personnel file, and should be expanded to include, among other things, a review of applicable company policies, at least one interview with potential witnesses, and a review of internal documents for any prior incidents similar to the action on which the complaint is based. The lack of effective anti-discrimination policies can be damaging to an employer’s case. On the other hand, a well-publicized, strictly enforced, non-discrimination policy can prove invaluable to an employer defending against a charge of discrimination. By reviewing its policies, an employer also may discover that the complaining employee did not follow proper company procedure in reporting the complaint. All of this information can be used by the employer in responding to the complaint. A reasonable cause determination indicates that â€Å"it is more likely than not† that illegal discrimination took place. A no reasonable cause determination means that the EEOC has not found sufficient evidence to support a finding of discrimination. While a â€Å"no cause† finding does not bar the complaining party from subsequently filing suit in state or federal court on the same claim, as a practical matter most employees do not pursue their claims after the EEOC issues a â€Å"no cause† finding. If the evidence establishes that discrimination has occurred, the employer  and the charging party will be informed of this in a letter of determination that explains the finding. EEOC will then attempt conciliation with the employer to develop a remedy for the discrimination (U.S. Equal Employment Opportunity Commission). If the case is successfully conciliated, or if a case has earlier been successfully mediated or settled, neither EEOC nor the charging party may go to court unless the conciliation, mediation, or settlement agreement is not honored (U.S. Equal Employment Opportunity Commission). If EEOC is unable to successfully conciliate the case, the agency will decide whether to bring suit in federal court. However, no statements made by any party during the conciliation process can be used in any subsequent lawsuit. If EEOC decides not to sue, it will issue a notice closing the case and giving the charging party 90 days in which to file a lawsuit on his or her own behalf (U.S. Equal Employment Opportunity Commission). CONCLUSION Employees who believe that they have been discriminated against by an employer, an employment agency, or a labor union have the right to file a charge of discrimination with the Equal Employment Opportunity Commission (EEOC). Employer’s need to ensure that discriminatory practice or action, if it did occur, is stopped, and that it does not occur again. By properly handling the charge at its early stages, an employer can reduce significantly, or possibly eliminate the potential liability. The Bureau of National Affairs, 2002. Retrieved September 11, 2006, from http://www.bna.comU.S. Equal Employment Opportunity Commission. Retrieved September 11, 2006, from http://www.eeoc.gov

Reflection on White Privilege

Reflective Analysis #2 Peddy McIntosh highlighted various unearned white privileges in her autobiographical article â€Å"White Privilege, Color and Crime: A Personal Account. † She illustrated the white privilege as an invisible package of unearned assets that one white person could count on cashing in each day. White people have these privileges given to them by the society in which they live in. The same society taught them to be ignorant and unawareness of these privileges. This system of unearned privileges established by white individuals made people of color feel oppressed. In this system being white is a norm and dominant power. Caucasians, who benefit most from the white privilege system in the United States, are more likely to be blinded to the existence of privilege system and take these privileges for granted it. In this reflection analysis, I will elaborate on most common white privileges mentioned by Peddy McIntosh through my personal experiences. As Peddy McIntosh distinguishes white race has unearned advantages over the color race that white people don’t even realize. Caucasians have a special provision, passports, and visas that color people among the world don’t have. For example, individuals from third world don’t get tourist visas to travel around the world and discover new places as the white do. From my personal experience, individuals in India who wants to travel around or settle in a different country don’t have these privileges. Nevertheless, they are unable to achieve their ambition. These individuals don’t have these provisions and privileges because the entire system is established based on white individuals. They’ve granted greater advantage among the same skin color individuals while limiting and lesser advantage towards the color people. Peddy McIntosh made an identical point that United States’ claim to be a democracy in which value is only rewarded to white people. She mentioned white individuals are unaware of these privileges and they are in process of benefitting from the advantages of racism. Another privilege McIntosh classifies is being surrounded by white individuals company. It is easier for a white person to fit in any community because majority of the communities are dominated by their race. For example, if a white person moves in a new house, they are pretty sure greater parts of their neighbors are same race as them. When I moved in the United States many years back, I felt left out and it was difficult for me to fit in because I was a minority. I was mocked by mostly white students about the way I dressed and teased about being different from them. White students don’t encounter these problems when they transfer from one school to another because they figured majority of the students they’ll be surrounded by will be same skin color as them. Another difficulty I had was shopping at a supermarket was finding my cultural food. It won’t be difficult for a white person to fit in a community and find similar food to their culture. A person doesn’t realize these privileges until they image themselves in color individuals’ shoes. In conclusion, Peggy McIntosh pointed in her article, white privileges don’t come from an individual person or flaw of a person. White privileges arise from the flaw of the system placed in a society. Therefore, if we want to change the society and equalize the privilege amongst whites and colors, then change must happen within the system. It is the system that influences individuals to act upon in the society. A great way, we can demise these privileges among white individuals, is through educating the whites and making them aware of these unearned benefits and privileges.